Bourne / Danielli Aspects of Cell Regulation

1. Auflage 2013
ISBN: 978-1-4832-6666-4
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 298 Seiten, Web PDF

Aspects of Cell Regulation deals with the various aspects of cellular control mechanisms. The book begins with a discussion of the role of hormones in the control of cell differentiation and biochemical control over the life of an organism. This is followed by separate chapters on an intracellular control problem, namely, the proper reproduction of cellular organelles and their apportionment between daughter cells at cell mitosis; cell mutants with different temporal order for macromolecular synthesis; and the control of a plant enzyme that converts triglycerides into carbohydrate during the early stages of postgerminative growth within seed cotyledon. Subsequent chapters deal with the possible role of mitochondria in changing the control mechanism of cells to that associated with carcinogenesis; the possibility of transforming genes being detectable in the genome after the transformation to neoplastic cell; the correlation between viruses and tumor cells; and whether viruses can originate from cells rather than coming before cells.

Autoren/Hrsg.

Bourne, G. H.

Danielli, J. F.

Inhaltsverzeichnis

1;Front Cover
;1
2;Aspects of Cell Regulation;4
3;Copyright Page;5
4;Table of Contents
;6
5;Contributors;10
6;Preface;12
7;INTERNATIONAL REVIEW OF CYTOLOGY;14
8;Chapter 1. Cellular Factors Which Modulate Hormone Responses: Glucocorticoid Action in Perspective;16
8.1;I. Introduction;16
8.2;II. Cell Entry;18
8.3;III. Steroid-Receptor Interaction;21
8.4;IV. Receptor Activation and Nuclear Translocation;25
8.5;V. Nuclear Binding Sites of the Steroid-Receptor Complex;26
8.6;VI. Mechanism of Gene Activation;28
8.7;VII. Summary;28
8.8;References;29
9;Chapter 2. Regulation of Genetic Activity by Thyroid Hormones;32
9.1;I. Introduction;32
9.2;II. Thyroid Hormones Participate in Cell Differentiation via Regulation of Nucleic Acid and Protein Syntheses;33
9.3;III. Binding of Thyroid Hormones to the Nuclear Receptor;35
9.4;IV. Binding of Thyroid Hormones to the Cytoplasmic Receptor;37
9.5;V. Binding of Thyroid Hormones to Other Intracellular Components;37
9.6;VI. Major Working Hypothesis on the Mechanisms of Genetic Activity Regulation by Thyroid Hormones;38
9.7;VII. Properties of the Thyroxine Cytoplasmic Receptor;41
9.8;VIII. The Role of the Thyroxine Cytoplasmic Receptor in Translocation of the Hormone from the Nucleus and Acceptance by Chromatin;43
9.9;IX. The Cytoplasmic Receptor as Mediator for the Action of Thyroid Hormones in the Nucleus;50
9.10;X. Interaction of the Hormone-Receptor Complex with DNA;53
9.11;XI. The TBPA-like Cytosol Receptor Is a Universal Intracellular Receptor of Thyroid Hormones;57
9.12;References;60
10;Chapter 3. The Partitioning of Cytoplasmic Organelles at Cell Division;64
10.1;I. Introduction;64
10.2;II. A Note on Terminology: Segregation and Partitioning;67
10.3;III. Numerical Partitioning of Organelles;67
10.4;IV. Compensating Replication;90
10.5;V. Numerical Partitioning of Organelle DNA;93
10.6;VI. Genetic Partitioning of Organelles;95
10.7;VII. Summary;101
10.8;References;102
11;Chapter 4. Cell Cycle Mutants;106
11.1;I. Introduction;106
11.2;II. Cell Cycle Concept;107
11.3;III. Cell Cycle Mutants;109
11.4;IV. Future Considerations;121
11.5;V. Conclusions;124
11.6;References;125
12;Chapter 5. Formation of Glyoxysomes;130
12.1;I. Introduction;130
12.2;II. Characterization of Glyoxysomes;131
12.3;III. Origin of Glyoxysomal Components;137
12.4;IV. General Conclusions;163
12.5;References;165
13;Chapter 6. Mitochondria, Cell Surface, and Carcinogenesis;172
13.1;I. Introduction;172
13.2;II. The Mitochondrial System;173
13.3;III. Tumor Mitochondria;175
13.4;IV. Antimitochondrial Activity of Carcinogens;177
13.5;V. Mitochondria and Cell Surface Characteristics;184
13.6;VI. Mitochondria and Intracellular Systems;193
13.7;VII. Mechanism of Mitochondrial Control;196
13.8;VIII. Conclusions and Prospects;198
13.9;References;200
14;Chapter 7. Transforming Genes of Tumor Cells;206
14.1;I. Demonstration of Altered DNA in Nonvirally Transformed Cells;206
14.2;II. Transforming DNA of Tumors Induced by Slowly Oncogenic Viruses;208
14.3;III. The Discrete Nature of These Transforming Sequences;209
14.4;IV. The Discovery of Tissue-Specific Oncogenes;210
14.5;V. Isolation of Active Oncogenes;212
14.6;VI. The Relationship of These Tumors to Other Known Oncogenes;213
14.7;VII. Additional Roles of one Genes;215
14.8;VIII. Perspectives;216
14.9;References;216
15;Chapter 8. Viral Carcinogenesis;218
15.1;I. Introduction;218
15.2;II. Oncogenic DNA Viruses;226
15.3;III. Retroviruses;245
15.4;References;255
16;Chapter 9. The Origin of Viruses from Cells;260
16.1;I. Introduction;260
16.2;II. Historical;261
16.3;III. Mechanisms for Change in Viruses;265
16.4;IV. The Evolutionary Age of Viruses;267
16.5;V. The Kinds of Cells;269
16.6;VI. The Kinds of Viruses;272
16.7;VII. Chlamydiae and Viruses Compared;275
16.8;VIII. Would a Cell . Virus Transition Be Possible?;278
16.9;IX. Origin of Viruses from Cellular Genetic Elements;281
16.10;X. Conclusions;288
16.11;References;293
17;INDEX;296