Protein-Carbohydrate Interactions in Infectious Diseases

Erscheinungsjahr 2006
ISBN: 978-0-85404-802-1
Verlag: RSC Publishing

Buch, Englisch, 250 Seiten, Format (B × H): 155 mm x 234 mm, Gewicht: 540 g

Protein-carbohydrate interactions is an exciting area of research with huge potential for development and exploration. These interactions are both widespread and diverse in biological processes and many play a crucial role in cellular recognition, attachment and adhesion. This is particularly true for host-pathogen interactions that lead to infectious diseases; as the surfaces of cells and pathogens display complex carbohydrate structures and carbohydrate binding proteins on their surface. Protein-Carbohydrate Interactions in Infectious Disease is part of the Biomolecular Science Series and provides a comprehensive overview of the subject, with contributions from leading experts in the field. Beginning with a general introduction, subsequent sections include: Atomic basis of protein-carbohydrate interactions, Structures and roles of Pseudomonas areuginosa lectins, Protein-carbohydrate interactions in enterobacterial infections, Retrocyclins: miniature lectins with potent antiviral activity, C-type lectin receptors that regulate pathogen recognition through the recognition of carbohydrates, Synthetic carbohydrate-based anti-malarial vaccines and glycobiology. With full colour throughout and an extensive bibliography this book is ideal for researchers interested in the area.

Zielgruppe

Researchers and professionals Bioorganic Chemistry, Biochemistry, general, Cell Biology

Autoren/Hrsg.

Bewley, Carole A

Fachgebiete

• Naturwissenschaften Chemie Organische Chemie Biochemie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Biowissenschaften Molekularbiologie

Inhaltsverzeichnis

Chemistry and Biology;

1: Atomic Basis of Protein-Carbohydrate Interactions. An Overview;

2: Mycobacterial Glycolipid and the Host: Role of Phenolic Glycolipids and Lipoarabinomannan;

3: Structures and Roles of Pseudomonas aeruginosa Lectins;

4: Protein-Carbohydrate Interactions in Enterobacterial Infections;

5: GM1 Glycomimetics and Bacterial Enterotoxins;

6: Retrocyclins: Miniature Lectins with Potent Antiviral Activity;

7: C-Type Lectin Receptors that Regulate Pathogen Recognition Through the Recognition of Carbohydrates;

8: Targeting Microbial Sialic Acid Metabolism for New Drug Development;

9: Synthetic Carbohydrate-Based Anti-Malarial Vaccines and Glycobiology;

10: Studies Towards a Rationally Designed Conjugate Vaccine for Cholera Using Synthetic Carbohydrate Antigens;

11: Carbohydrate Microarrays for High Throughput Analysis of Carbohydrate-Protein Interactions;

Über Autor(innen)

A Bewley, National Institute of Health, USA