Bioreaction Engineering

Modeling and Control
Softcover Nachdruck of the original 1. Auflage 2000
ISBN: 978-3-642-64103-9
Verlag: Springer

Buch, Englisch, 604 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 966 g

The book is intended to present various examples for reactor and process modeling and control as well as for metabolic flux analysis and metabolic design at an ad­ vanced level. In Part A, General principles and techniques with regard to reactor and process models, process control, and metabolic flux analysis are presented. In addition the accuracy, precision, and reliability of the measured data are discussed which are ex­ tremely important for process modeling and control. A virtual bioreactor system is presented as well, which can be used for the training of students and operators of industrial plants and for the development of advanced automation tools. In Part B, the General principles are applied for particular bioreactor models. It covers the application of the computational fluiddynamic (CFD) technique to stirred tank and bubble column bioreactors. Different solution methods are presented: the Reynolds-averaging of the turbulent Navier-Stokes equations and modeling of the Reynolds stresses with an appropriate turbulence (k-ee) model, and the Euler (two fluid model), as well as the Euler-Langrange approaches.

Zielgruppe

Research

Autoren/Hrsg.

Bellgardt, K. -H.

Schügerl, K.

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Chemische Reaktionstechnik (incl. Katalyse, Elektrolyse)
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie
• Naturwissenschaften Chemie Organische Chemie Biochemie

Inhaltsverzeichnis

The Need for Modeling and Control in Biotechnical Processes.- Some Modeling Basics.- Structure and Operation of Biotechnical Plant.- References.- A General Principles and Techniques.- 1 Bioreactor Models.- 2 Bioprocess Models.- 3 Metabolic Flux Analysis.- 4 Accuracy and Reliability of Measured Data.- 5 Bioprocess Control.- 6 On-Line Simulation Techniques for Bioreactor Control Development.- B Application of General Principles for Reactor Models.- 7 Application of Computational Fluiddynamics (CFD) to Modeling Stirred Tank Bioreactors.- 8 Bubble Column Bioreactors.- C Application of General Principles for Process Models Including Control.- 9 Baker’s Yeast Production.- 10 Modeling of the Beer Fermentation Process.- 11 Lactic Acid Production.- 12 Control Strategies for High-Cell Density Cultivation ofEscherichia coli.- 13 ?-Lactam Antibiotics Production withPenicillium chrysogenum and Acremonium chrysogenum.- D Metabolite Flux Analysis, Metabolic Design.- 14 Quantitative Analysis of Metabolic and Signaling Pathways inSaccharomyces cerevisiae.- 15 Metabolic Analysis ofZymomonas mobilis.- 16 Metabolic Flux Analysis ofCorynebacterium glutamicum.- 17 Analysis of Metabolic Fluxes in Mammalian Cells.