Barthold / Davisson / Smith The Mouse in Biomedical Research

History, Wild Mice, and Genetics
2. Auflage 2006
ISBN: 978-0-08-046906-5
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 1, 352 Seiten, Web PDF

Reihe: American College of Laboratory Animal Medicine

History, Wild Mice, and Genetics, the first volume in the four volume set, The Mouse in Biomedical Research, provides information about the history, biology and genomics of the laboratory mouse (Mus musculus), as well as basic information on maintenance and use of mouse stocks. Mouse origins and relationships are covered in chapters on history, evolutionary taxonomy and wild mice. Genetics and genomics of the mouse are covered in chapters on genetic nomenclature, gene mapping, cytogenetics and the molecular organization of the mouse genome. Maintenance of laboratory mice is described in chapters on breeding systems for various types of strains and stocks and genetic monitoring. Use of the mouse as a model system for basic biomedical research is described in chapters on chemical mutagenesis, gene trapping, pharmacogenetics and embryo manipulation. The information in Volume 1 serves as a primer for scientists new to the field of mouse research.

Autoren/Hrsg.

Barthold, Stephen

Davisson, Muriel

Smith, Abigail

Inhaltsverzeichnis

1;Front Cover;1
2;The Mouse in Biomedical Research: History, Wild Mice, and Genetics;4
3;Copyright Page ;5
4;Table of Contents;6
5;List of Reviewers;11
6;List of Contributors;12
7;Foreword;14
8;Preface;16
9;Chapter 1. Building a Better Mouse: One Hundred Years of Genetics and Biology ;18
10;Chapter 2. Systematics of the genus Mus;30
11;Chapter 3. The Secret World of Wild Mice;42
12;Chapter 4. Breeding Systems: Considerations, Genetic Fundamentals, Genetic Background, and Strain Types;70
13;Chapter 5. Mouse Strain and Genetic Nomenclature: an Abbreviated Guide;96
14;Chapter 6. The Mouse Genome;116
15;Chapter 7. Gene Mapping;132
16;Chapter 8. Genetic Monitoring;152
17;Chapter 9. Cytogenetics;162
18;Chapter 10. Mouse Embryology: Research Techniques and a Comparison of Embryonic Development between Mouse and Man;182
19;Chapter 11. Gamete and Embryo Manipulation;228
20;Chapter 12. Chemical Mutagenesis in Mice;242
21;Chapter 13. Gene-Specific Mutagenesis;278
22;Chapter 14. Gene Transfer Studies Using Mouse Models;284
23;Chapter 15. Mouse and Human Pluripotent Stem Cells;298
24;Chapter 16. Drugs and the Mouse: Pharmacology, Pharmacogenetics, and Pharmacogenomics;306
25;Index;338
26;Colour Plates;345