Nitroalkanes

Synthesis, Reactivity, and Applications
1. Auflage 2021
ISBN: 978-3-527-34745-2
Verlag: WILEY-VCH

Buch, Englisch, 298 Seiten, Format (B × H): 173 mm x 249 mm, Gewicht: 748 g

Discover a comprehensive exploration of recent progress in the preparation of nitroalkanes from two leading voices in the field

Nitroalkanes: Synthesis, Reactivity, and Applications delivers a thorough summary of the importance of nitroalkanes in organic synthesis. The book covers their preparation, transformation into other functional groups, like carbonyls and amines, and their use in the formation of single carbon-carbon or double carbon-carbon bonds. The distinguished authors have included chapters on acyclic and cyclic alpha-nitro ketones as well as the synthesis of cyclopropanes and spiro ketals.

The book provides treatments of the application of nitroalkanes for the synthesis of important heterocycles, poly-functionalized structures, natural products, and compounds of biological and pharmaceutical interest. A one-stop resource in a topic that hasn???t been fully addressed by any other book in decades, this book covers the most important synthetic routes toward nitroalkanes.

Readers will also benefit from the inclusion of:

- A thorough introduction to the synthesis of nitroalkanes, as well as the transformation of the nitro group into other functionalities
- An exploration of the formation of C-C single bonds, C=C double bonds, and the breaking of C3C bonds from cyclic alpha-nitro ketones
- Discussions of acyclic alpha-nitro ketones, nitroalkanes as precursors of cyclopropanes, and the synthesis of spiro ketals
- An examination of the preparation and synthetic applications of 1,3-Dinitroalkanes

Perfect for organic chemists, natural products chemists, and catalytic chemists, Nitroalkanes: Synthesis, Reactivity, and Applications will also earn a place in the libraries of medicinal chemists seeking a one-stop resource for the most recent developments in the preparation of nitroalkanes, their functionalization, and their applications.

Autoren/Hrsg.

Ballini, Roberto

Palmieri, Alessandro

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Verfahrenstechnik, Chemieingenieurwesen
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Naturwissenschaften Chemie Organische Chemie

Inhaltsverzeichnis

Introduction
Synthesis of Nitroalkanes
Reduction of the Nitro Group into Amines
The Nef Reaction
Nitroaldol (Henry) Reaction
Conjugate Addition of Nitroalkanes to Electron-Poor Alkenes (Michael Reaction)
Formation of C,C Bond by Coupling Nitroalkanes with Arylhalides
Synthesis and Reactivity of 1,3-Dinitroalkanes
Formation of Carbon-Carbon Double Bonds via Nitrous Acid Elimination (NAE)
alpha-Nitrocycloalkanones, Synthesis and Reactivity
Acyclic alpha-Nitro Ketones: Synthesis and Reactivity
Nitro Cyclopropanes: Synthesis and Applications
Nitroalkanes as Source of Dicarbonyls
Nitroalkanes as Source of Spiroketals

Über Autor(innen)

Roberto Ballini is Professor of Organic Chemistry at the University of Camerino, Italy. His research is mainly dedicated to organic synthesis, with particular emphasis on aliphatic nitro compounds. He has published more than 250 articles and edited two books.
 
Alessandro Palmieri is Associate Professor at the University of Camerino, Italy. He develops eco-friendly processes for the formation of C-C and C-X bonds, and flow chemical protocols for the synthesis of fine chemicals. He is co-author of 100 publications.