Balci Reaction Mechanisms in Organic Chemistry

1. Auflage 2021
ISBN: 978-3-527-83460-0
Verlag: Wiley-VCH
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 620 Seiten, E-Book

Understanding organic reaction mechanisms is the key for understanding organic chemistry. That is the concept of this unique textbook which supports the students perfectly to understand organic chemistry in a very comprehensive way. Includes a problem & solution section, too.

Autoren/Hrsg.

Balci, Metin

Inhaltsverzeichnis

BASIC CONCEPTS

Covalent Bonding and Hybridization

Electrophiles and Nucleophiles

Inductive and Mesomeric Effects

Formal Charge And Oxidation Number

Acids And Bases

Reaction Kinetics And Energy Diagrams

 

NUCLEOPHILIC SUBSTITUTION REACTIONS

Unimolecular Substitution Reactions SN1

Stereochemistry in SN1 Reactions

Optical Activity

Bimolecular Substitution Reactions SN2

Stereochemistry of SN2 Reactions

Nucleophilic Substitution On Allylic Systems: Allylic Rearrangement

Internal Nucleophilic Substitution Reaction SNi

Neighboring Group Participation in Nucleophilic Substitution Reactions

Ambident Nucleophiles

Various Nucleophilic Substitution Reactions

 

ELIMINATION REACTIONS

Unimolecular Elimination Reactions, E1

Bimolecular Elimination Reactions, E2

Unimolecular Conjugate Base

Halogene Elimination

Hofmann Elimination: Quaternary Ammonium Salts

Pyrolitic Eliminations: Intramolecular cis-Elimination Reactions

Elimination at the Bridgehead: Bredt?s Rule

 

ADDITION REACTIONS

Halogen Addition To Double Bonds: Halogenation

Addition of Hydrogen Halides to Double Bonds: Markovnikov?s Rule

Anti-Markovnikov Addition of Hydrogen Halides to Alkenes

Addition of Water to Alkenes

Oxymercuration and Demercuration

Hydroboration of Alkenes: Anti-Markovnikov Hydration

Epoxidation of the Alkenes

Vicinal cis-Dihydroxylation

Dihydroxylation via PIFA

Enzymatic Dihydroxylation

Ozonolysis: Oxidative Cleavage of Alkenes

Reduction of Alkenes

Addition to Conjugated Dienes

 

CARBONYL COMPOUNDS AND THEIR REACTIONS

Structure-Reactivity Relationships

Reactions of Carbonyl Compounds

Carbonyl Addition Reactions

Umpolung: Polarity Inversion of Aldehyde Carbonyl Group

Reactions of Aldehydes and Ketones with Amines

Reduction of Carbonyl Groups

Reaction of Carbonyl Groups with Organometallic Compounds

Reaction of Carbonyl Groups with Ylides

Phosphonium Ylides and Wittig Reaction

Reactivity of alpha-Carbon Atom

Keto-Enol Tautomerism

Proton-Deuterium Exchange

alpha-Halogenation of Ketones and Aldehydes: Haloform Reaction

Hell-Volhard-Zelinsky Reaction

alpha-Alkylation of Carbonyl Compounds

Enolates Derived from 1,3-Dicarbonyl Compounds

Condensation Reactions of Carbonyl Compounds

Typical Reactions of Acids and Esters

Transesterification

 

AROMATIC COMPOUNDS

Structure of Benzene

Aromatic, Antiaromatic, and Nonaromatic Compounds

Determination of the Molecular orbitals of Aromatic Compounds

What are the criteria for aromaticity? How does one quantify aromaticity?

Homoaromaticity

Möbius Aromaticity

Aromatic Ions

Annulenes

Aromaticity in Fused Systems

Aromaticity in Heterocyclic Compounds

Electrophilic Aromatic Substitution: Chemistry of Benzene

Reactivity of Monosubstituted Benzene Derivatives

Directing Effects of Substituents: Activating Groups

Electrophilic Aromatic Substitution on Disubstituted Benzenes

Functionalization of the Side Chain Substituents of Benzene

Nucleophilic Aromatic Substitution Reactions

Polycyclic Aromatic Compounds

Benzenoid Aromatic Compounds

 

REACTIVE INTERMEDIATES

Carbocations

Carbanions

Carbenes

Nitrenes

Radicals

Singlet Oxygen

 

PERICYCLIC REACTIONS

Woodward Hoffmann Rules

Frontier Orbitals

Electrocyclic Reactions

Application of Woodward Hoffmann Rules

Correlation Diagrams

Cycloaddition Reactions

Secondary Orbital Interaction

Orbital Coefficients

Sigmatropic Reactions

Cope and Claisen Rearrangement

 

CARBON-CARBON (C-C) COUPLING REACTIONS

History

Mizoroki-Heck Coupling Reaction

Stille-Coupling Reaction

Suzuki-Miyaura Coupling Reaction

Negishi-Coupling Reaction

Sonogashira-Coupling Reaction

Kumada-Coupling Reaction

Hiyama-Coupling Reaction

Hiyama-Denmark Coupling

Buchwald-Hartwig Coupling

Tsuji-Trost Coupling

Palladium-catalyzed Carbonylation Reactions

Carbonylative Coupling Reactions with Organometallic Reagents

Mo(CO)6-Mediated Carbonylation

Über Autor(innen)

Metin Balci is Professor Emeritus of the Middle East Technical University in Ankara. He received his Ph.D. degree in 1976 from the University of Cologne, where he worked with Professor Emanuel Vogel. He did post-doctoral work with Professors Harald Günther (Siegen, Germany), Waldemar Adam (Puerto Rico) and W. M. Jones (Florida). In 1980 he joined the Department of Chemistry at the Atatürk University and he has been a full professor there since 1987. In 1997 he moved to the Middle East Technical University in Ankara upon reputation.

Metin Balci has received several prices: In 1983 "Junior Research Prize" and "Scientific Prize" in 1989 from the Scientific and Technical Research Council of Turkey and the Best Teacher Award in 2000, 2003, 2004 at the Middle East Technical University (METU). Furthermore, he received METU "Academic Achievement Award", (2000-2015). His main research interest include synthesis of cyclitols, endoperoxides, cyclic strained compounds, bromine chemistry, and heterocyclic compounds. He has published 280 scientific papers and he retired in 2015.