Biochemical, Pharmacological, and Clinical Aspects of Nitric Oxide

Softcover Nachdruck of the original 1. Auflage 1995
ISBN: 978-1-4613-5777-3
Verlag: Springer US

Buch, Englisch, 248 Seiten, Paperback, Format (B × H): 170 mm x 244 mm, Gewicht: 462 g

A decade ago, for most scientists investigating various issues in life sciences the word "NO" was used in a negative context. It is astounding to observe how recently researchers are addressing the issue of NO, namely, nitric oxide, in over fifty publications weekly. Science journal, while naming nitric oxide: "Molecule of the Year" (December 1992), said it all: "NO news is good news. " For a long period of time NO was considered as a pollutant and every ecology­ minded person tried to eliminate it. It was the discovery of NO involvement in the process of host killing by macrophages and several years later the finding that EDRF is none else but NO, that promoted this field. Nitric oxide's major role in the control of blood pressure is merely one factor of an extensive list of effects and functions attributed to it. NO is implicated in long-term potentiation (LPT), a principal process involved in memory consolidation and it is considered as the main biochemical substance responsible for penile erection. It should be noted that additional roles for NO are discovered continuously as many laboratories join the quest for the mystery of this small molecule. The observation that NO is involved in various biological processes is not unique, as other second messengers (i. e., cyclic AMP), participate in a diverse set of functions.

Zielgruppe

Research

Autoren/Hrsg.

Allon, N.

Weissman, B. A.

Shapira, S.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Naturwissenschaften Biowissenschaften Tierkunde / Zoologie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Physik Angewandte Physik Biophysik

Inhaltsverzeichnis

The Nitric Oxide Signal Transduction System.- Chemistry and Biochemistry of Nitric Oxide.- Mechanisms of Mammalian Nitric Oxide Biosynthesis.- Nitric Oxide Synthase Inhibitors: Mechanism of Action and in Vivo Studies.- Biosynthesis of Nitric Oxide.- Mechanisms of Shear Stress-Dependent Endothelial Nitric Oxide Release: Cardiovascular Implications.- Determination of Nitric Oxide Levels by Fluorescence Spectroscopy.- Pharmacology and Drug Development.- S-Nitrosothiols- Correlation of Biological Chemistry with Physiological Actions.- Initial Clinical Experience with the Intracavernous Application of the Nitric Oxide Donor Sin-1 in the Treatment of Patients with Erectile Dysfunction.- Nitric Oxide-Induced Lymphocyte Activation: A Role for G Proteins.- Coronary Haemodynamic Profile of the New Nitro-Ester Derivative ITF 296 in the Conscious Dog.- Nitric Oxide in Amphibian Photoreceptors.- The involvement of L-Arginine - Nitric Oxide Pathways in the Anti-Rickettsial Activity of Macrophagelike Cells.- Modulation of LDL and Oxy-LDL Catabolism by NO-Donors and PGE2 in Human Peripheral Blood Lymphocytes and Rat Macrophages.- Nitric Oxide and the Respiratory and Cardiovascular Systems.- The Role of Nitric Oxide in Nonadrenergic Noncholinergic Neural Relaxation of Mammalian Airway Smooth Muscle.- Nitric Oxide: A Putative Modulator of Muscarinic Receptor in the Airways Smooth Muscles.- Comparative Effects of N?-Nitro-L-arginine, N?-Nitro-L-arginine Methyl Ester, and N?-Nitro-L-arginine Benzyl Ester on Vasodilator responses to Acetylcholine and Substance P.- Vascular Responses to Endothelin-1 in Conscious Rats Modulation by Endogenous Nitric Oxide.- Stimulation of Endogenous NO-Production Influences the Dilation of the Capillary Microvasculature in Vivo.- Induction ofNADPH-Diaphorase Activity with Endotoxin in Rat Heart and Spleen in Vivo.- Vasculoprotective Actions of Nitric Oxide.- Nitric Oxide - An Endogenous Inhibitor of Balloon Catheter-Induced Intimal Hyperplasia.- Generation and Roles of Nitric Oxide in Anaphylaxis.- Nitric Oxide and Brain Functions.- Nitric Oxide and Cerebrovascular Regulation.- Multiparametric Responses to Cortical Spreading Depression under Nitric Oxide Synthesis Inhibition.- The Effects of Sodium Nitroprusside and L-glutamate on the Regulation of the Cytoskeletal Associated Protein Tau in Primary Cultured Neurons from Rat.- Brain Lesion and Nitric Oxide Synthase/NADPH-Diaphorase: A Light and Electron Microscopical Study.- Dose-Dependent Effects of Nitric Oxide on in Vivo and in Vitro Neuronal Functions.- Inhibition of Nitric Oxide Production Impairs Specific Cognitive Processes in Rats.- The Effect of Aging on NOS Activity in the Rat Hippocampus and Its Relation to Cognitive Functions.- Authors Index.