Aldini / Yeum / Niki Biomarkers for Antioxidant Defense and Oxidative Damage

Principles and Practical Applications
1. Auflage 2011
ISBN: 978-0-470-96175-9
Verlag: John Wiley & Sons
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 380 Seiten, E-Book

Biomarkers for Antioxidant Defense and Oxidative Damage:Principles and Practical Applications critically evaluates thebasic concepts and methodologies of conventional biomarkers as wellas current state-of-the-art assays for measuring antioxidantactivity/oxidative stress and their practical applications. .Biomarkers for Antioxidant Defense and Oxidative Damage:Principles and Practical Applications will be of a greatinterest to scientists who are involved in basic research onoxidation, applied scientists evaluating the effects ofnutraceuticals or pharmaceutical compounds on antioxidantactivity/oxidative stress, and physicians who want to understandthe degree of oxidative damage in patients with certain chronicdiseases.
Discovering sensitive and specific biomarkers for systemicoxidative damage is essential to understand the role of oxidativestress in human disease. Once these roles are clearly understood,we are able to identify novel drug and nutraceutical targets. Thisvolume goes beyond conventional analytical methods of measuringoverall antioxidant activity and provides insight to the discoveryof biomarkers that reveal information on specific areas ofoxidative stress. Contributed by an international list of experts,Biomarkers for Antioxidant Defense and Oxidative Damage:Principles and Practical Applications describes bothconventional biomarkers and recent developments in this area.
Special Features:
* Discusses conventional biomarkers as well as recent advancesfor measuring antioxidants and oxidative stress
* Biomarkers for lipid peroxidation: isoprostane,hydroxyloctadecaenoic acid, oxysterols, and reactive carbonylspecies from lipid peroxidation
* Biomarkers for protein oxidation: carbonylation, tyrosineoxidation, ubiquitin-conjugation
* Biomarkers for DNA oxidative damage: comet assay, hydroxylatednucleotides, and exocylcic DNA adducts
* Recently developed biomarkers from cutting-edge technology

Autoren/Hrsg.

Aldini, Giancarlo

Yeum, Kyung-Jin

Niki, Etsuo

Russell, Robert M.

Inhaltsverzeichnis

Preface
Contributors
1. Antioxidant Activity and Oxidative Stress: An Overview(Kyung-Jin Yeum, Robert M. Russell, and GiancarloAldini).
2. Enzymatic Antioxidant Defenses (Sayuri Miyamoto,Hirofumi Arai, and Junji Terao).
3. Antioxidants as Biomarkers of Oxidative Stress(Ikuyo Ichi and Shosuke Kojo).
4. LDL Oxidation as a Biomarker of Antioxidant Status(Mohsen Meydani, EunHee Kong, and Ashley Knight).
5. The Isoprostanes: Accurate Markers and Potent Mediators ofOxidant Injury in Vivo (Joshua D. Brooks, Brian E.Cox, Klarissa D. Hardy, Stephanie C. Sanchez, Sonia Tourino, TylerH. Koestner, Jocelyn R. Hyman-Howard, and Ginger L. Milne).
6. Hydroxyoctadecadienoic Acid (HODE) as a Marker of LinoleicAcid Oxidation (Yasukazu Yoshida and Etsuo Niki).
7. Oxysterols: Potential Biomarkers of Oxidative Stress(Luigi Iuliano and Ulf Diczfalusy).
8. Lipid Peroxidatin Originatingalpha,beta-unsaturated Aldehydes andTheir Metabolites as Biomarkers (FrançoiseGuéraud).
9. Oxidation Modification of Proteins: An Overview(Paul J. Thornalley and Naila Rabbani).
10. Immunochemical Detection of Lipid Peroxidation-specificEpitopes (Koji Uchida).
11. Mass Spectrometric Strategies for Identification andCharacterization of Carbonylated Peptides and Proteins(Marina Carini and Marica Orioli).
12. Nitrotyrosine: Quantitative Analysis, Mapping inProteins, and Biological Significance (José Souza,Silvina Bartesaghi, Gonzalo Peluffo, and Rafael Radi).
13. Ubiquitin Conjugates: A Sensitive Marker of OxidativeStress (Fu Shang and Allen Taylor).
14. Covalent Modifications of Albumin Cys34 as a Biomarker ofMild Oxidative Stress (Giancarlo Aldini, Kyung-Jin Yeum, andGiulio Vistoli).
15. Protein S-glutathionilation andS-cysteinilation (Graziano Colombo, AldoMilzani, Roberto Colombo, and Isabella Dalle-Donne).
16. DNA Oxidation, Antioxidant Effects, and DNA RepairMeasured with the Comet Assay (Mária DuSinskáand Andrew R. Collins).
17. Hydroxylated Nucleotides: Measurement and Utility asBiomarkers for DNA Damage, Oxidative Stress, and AntioxidantEfficacy (Phyllis E. Bowen).
18. Exocyclic DNA Adducts as Biomarkers of AntioxidantDefense and Oxidative Stress (Roger W.L. Godschalk).
Index.

Über Autor(innen)

Giancarlo Aldini, Ph.D., Department of Pharmaceutical
Sciences "Pietro Pratesi", Università degli Studi diMilano, Milan, Italy
Kyung-Jin Yeum, Ph.D., Jean Mayer USDA-Human NutritionResearch Center on Aging, Tufts University, Boston, MA, USA.
Etsuo Niki, Ph.D., , Health Research Institute, NationalInstitute of Advanced Industrial Science & Technology, Osaka,Japan.
Robert M. Russell, M.D., Office of Dietary Supplements,National Institutes of Health, 6100 Executive Blvd., Bethesda, MD20892-7517, USA