Inflammasomes: Clinical and Therapeutic Implications

1. Auflage 2018
ISBN: 978-3-319-89389-1
Verlag: Springer International Publishing

Buch, Englisch, Band 108, 400 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 776 g

Reihe: Experientia Supplementum

The inflammasome is a protein complex composed of an intracellular sensor—typically a Nod-like receptor (NLR), the precursor procaspase-1, and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrates, IL-1ß and IL-18. The inflammasome has been implicated numerous diseases, and blockade of inflammasome-derived IL-1ß has beneficial effects on several of these diseases. Different books have been edited about the biology of inflammasomes and about methods to study, however, the implication of this complex in the different diseases and pathological conditions show the need of a book about the clinical implications and therapeutic options. This project will show the context where inflammasomes are being studied and the molecular implications in the medical and clinical contexts.

Other important topic of the inflammasomes will be the development of pharmacological inhibitors in order to improve new clinical applications. In this sense, we can find new drugs with inhibitory effects or old drugs with an inhibitory potential effect. There is a need for re-establishing the real benefits of the inflammasome inhibitions in pathological situations and the management of the differents diseases where inflammasomes are implicated.

Zielgruppe

Research

Autoren/Hrsg.

Alcocer-Gómez, Elísabet

Cordero, Mario D.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Biochemie (med.)

Inhaltsverzeichnis

Chapter 1: Bases of the inflammasomes in the clinical practice. A brief introduction.- Chapter 2: The Inflammasomes in Cardiovascular Disease.- Chapter 3: Inflammasomes in CNS diseases.- Chapter 4: Lung Diseases.- Chapter 5: Traumatic Injury.- Chapter 6: Inflammasome in the pathogenesis of pulmonary diseases.- Chapter 7: Inflammasome and Oral Diseases.- Chapter 8: Inflammasomes in the kidney.- Chapter 9: Pro-inflammatory actions of red blood cell-derived DAMPs.- Chapter 10: Role of Inflammasomes in the Development of Gastrointestinal Diseases.- Chapter 11: Inflammasomes in bone diseases.- Chapter 12: Inflammasome in Cancer.- Chapter 13: Aging and the inflammasomes.- Chapter 14: Genetics of inflammasome.- Chapter 15: Therapeutic implications of the inflammasomes.

Über Autor(innen)

Mario D Cordero is Research Associate at the University of Sevilla. He studies the role of inflammasomes in metabolic and cardiovascular diseases, with special attention on the implication of NLRP3 in age-associated diseases. He is also involved in the evaluation of inflammasome inhibitors in rare diseases.Dr Cordero is one of the editors of volume no. 107 on AMP-activated protein kinases in the same series.  

Elísabet Alcocer-Gómez is Research Associate at the University of Sevilla. Her scientific interest is the implication of inflammasome complexes in psychiatric diseases and the effect of psychiatric drugs on the inhibition or induction of inflammasome activation.