Advances in Immunology

1. Auflage 1993
ISBN: 978-0-08-057829-3
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 53, 342 Seiten, Web PDF

Reihe: Advances in Immunology

For 30 years, this esteemed serial has provided students and researchers with the latest information in Immunology. You can continue to rely on Advances in Immunology to provide you with critical reviews that examine subjects of vital importance to the field through summary and evaluation of current knowledge and research. The articles stress fundamental concepts, but also evaluate the experimental approaches. Each volume of Advances in Immunology contains a subject index as well as the contents of recent volumes. Each chapter includes references.Researchers and students in microbiology, genetics and immunocology will use this invaluable serial to stay updated on the latest advances for years to come.Advances in Immunology will keep you informed on such broadly defined subjects as: - Immunochemistry - Antibody synthesis - Biological action of antibodies - Immunological unresponsiveness - Mechanisms in innate and acquired immunity not involving antibodies - Specialized immunological techniques

Autoren/Hrsg.

Inhaltsverzeichnis

1;Front Cover;1
2;Advances in Immunology, Volume 53;4
3;Copyright Page;5
4;Contents;6
5;Chapter 1. Lymphokine and Cytokine Production by FceRI+ Cells;10
5.1;I. Introduction;10
5.2;II. Biology of blast Cells and Basophils;10
5.3;III. Lymphokine Production by Transformed Murine Mast Cells;13
5.4;IV. Lymphokine Production by Factor-Dependent Miirine Mast Cell Lines;15
5.5;V. Lymphokine Production by Murine Peritoneal, Splenic, and Bone Marrow FceRI+ Cells;18
5.6;VI. Lymphokine Production by Human FceR+ Cells;23
5.7;VII. IL-4 Production by FceRI+ Cells in Infected or Iinmunized Mice;24
5.8;VIII. Does IL-4 Production by FceR+ Cells Play an Important Role in Determination of Lymphokine-Producing Phenotypes of CD4+ T Cells?;26
5.9;IX. Signaling Mechanisms Leading to IL-4 Production;28
5.10;X. Conclusion;31
5.11;References;32
6;Chapter 2. The Leukemia Inhibitory Factor and Its Receptor;40
6.1;I. Introduction;40
6.2;II. Purification and Molecular Cloning of the Leukemia Inhibitory Factor;40
6.3;III. The Leukemia Inhibitory Factor in Development;42
6.4;IV. Roles for LIF in Disease: Inflammation and Cachexia?;46
6.5;V. Molecular Characterization of the Leukemia Inhibitory Factor Receptor;47
6.6;VI. Life without LIF: The LIF Knockout Mouse;57
6.7;VII. Conclusions;58
6.8;References;59
7;Chapter 3. The Role of CD4 ond CD8 in T Cell Activation and Differentiation;68
7.1;I. Introduction;68
7.2;II. Function of CD4 and CD8 in T Cell Activation;68
7.3;III. Role of CD4 and CD8 i n T Cell Differentiation;103
7.4;References;123
8;Chapter 4. B Lymphopoiesis in the Mouse;132
8.1;I. Introduction;132
8.2;II. B Cells from Embryonic Stem Cells;133
8.3;III. Differential Expression of Lineage-Related Markers during B Cell Development in Different Body Sites;134
8.4;IV. Proliferation and Differentiation Capacities of B Cell Subpopulations;136
8.5;V. Possible Functions of the Surrogate L Chain in B Cell Differentiation;145
8.6;VI. Differentiation of Pre-B Cells to B Cells;149
8.7;VII. Genetic Defects Expressed in the B Lineage that Lead to Autoimmune Disease;153
8.8;References;156
9;Chapter 5. Compartmentalization of the Peripheral Immune System;166
9.1;I. Introduction;166
9.2;II. T Lymphocytes in Peripheral Compartments;168
9.3;III. B Cells in Peripheral Compartments;186
9.4;IV. Generation of Compartments;196
9.5;V. The Significance of Compartments;208
9.6;VI. Summary;213
9.7;References;214
10;Chapter 6. Immunological Memory;226
10.1;I. Introduction;226
10.2;II. Longevity and Maintenance of Immunological Memory;227
10.3;III. The T Cell Immune System and Immunological Memory;233
10.4;IV. The B Cell Immune System and Immunological Memory;239
10.5;V. The Life Span of T and B Cells and Relevance to Memory;247
10.6;VI. The Migration and Localization of Naive and Memory Cells;251
10.7;VII. Immunological Memory, Tolerance, and Autoimmunity;258
10.8;VIII. Concluding Remarks;262
10.9;References;263
11;Chapter 7. Recognition of Bacterial Endotoxins by Receptor-Dependent Mechanisms;276
11.1;I. Introduction;276
11.2;II. Structure of Bacterial Lipopolysaccharide;277
11.3;III. Recognition of Lipid A by Receptor-Mediated Mechanisms;280
11.4;IV. Lipid A Structure-Function Relationships: Identification of Lipid A Antagonists;281
11.5;V. Identification of Membrane Proteins that Interact with Lipid;283
11.6;VI. The Role of the LBP/CD14 Pathway in LPS-Induced Macrophage Stimulation;290
11.7;VII. Summary;295
11.8;References;296
12;Chapter 8. Cell Adhesion Molecules as Targets of Autoantibodies in Pemphigus and Pemphigoid, Bullous Diseases Due to Defective Epidermal Cell Adhesion;300
12.1;I. Introduction;300
12.2;II. Clinical, Histologic, and Innmunopathologic Findings;300
12.3;III. Immunochemical Characterization of Pemphigoid and Pemphigus Antigens;306
12.4;IV. cDNA Cloning of Autoantigens;314
12.5;V. Conclusions and Future Directions;324
12.6;References;325
13;Index;336
14;Content of Recent Volumes;348