Advances in Immunology

1. Auflage 2000
ISBN: 978-0-08-052236-4
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 75, 360 Seiten, Web PDF

Reihe: Advances in Immunology

Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Autoren/Hrsg.

Inhaltsverzeichnis

1;Cover;1
2;Title Page;370
3;Advance in Immunology;4
4;Copyright Page;5
5;Contents;6
6;Contributors;10
7;Chapter 1. Exploiting the Immune System: Toward New Vaccines against Intracellular Bacteria;12
7.1;I. Introduction;12
7.2;II. General Comments;13
7.3;III. Infectious Diseases Caused by Intracellular Bacterial Pathogens;18
7.4;IV. Intracellular Bacteria, Their Niches in the Host Cell, and the Immune Responses Elicited;23
7.5;V. Vaccines;37
7.6;VI. From Genomes to Antigens;70
7.7;VII. Concluding Remarks and Outlook;72
7.8;References;6
8;Chapter 2. The Cytoskeleton in Lymphocyte Signaling;100
8.1;I. Introduction;100
8.2;II. Overview;101
8.3;III. Current View of the Regulation of Actin Polymerization in Cytoskeletal Rearrangements;105
8.4;IV. The Vav Family of Guanine Nucleotide Exchange Factors;106
8.5;V. The Regulation of Actin by Rac;109
8.6;VI. WASP and the Wiskott–Aldrich Syndrome;111
8.7;VII. WASP and the Control of Actin;115
8.8;VIII. Shared Aspects in the Phenotype of WASP- and Vav-Deficient Mice;118
8.9;IX. Actin Polymerization and the Propagation of Signals to the Nucleus;119
8.10;References;121
9;Chapter 3. TGF-ß Signaling by Smad Proteins;126
9.1;I. Abstract;126
9.2;II. The TGF-B Superfamily;126
9.3;III. Serine/Threonine Kinase Receptors;127
9.4;IV. Structure and Function of Smads;130
9.5;V. Cytoplasmic Actions of Smads;137
9.6;VI. Actions of Smads in the Nucleus;139
9.7;VII. I-Smads;146
9.8;VIII. Signaling Cross-Talk;148
9.9;IX. Roles of Smads in Human Cancer;151
9.10;X. In Vivo Functions of Smads: Analyses by Gene Targeting;153
9.11;XI. Perspectives/Conclusion;154
9.12;References;156
10;Chapter 4. MHC Class II-Restricted Antigen Processing and Presentation;170
10.1;I. Introduction;170
10.2;II. The MHC Class I and Class II Pathways;171
10.3;III. Structure of MHC Class II Complexes;173
10.4;IV. Biosynthesis and Assembly of MHC Class II/Invariant Chain Complexes;182
10.5;V. Entry of MHC Class II/Invariant Chain Complexes into the Endocytic Pathway;184
10.6;VI. Subcellular Organelles Involved in Antigenic Peptide Loading onto Class II Molecules: The MHC Class II Compartments;187
10.7;VII. Transport of MHC Class II Complexes to the Cell Surface;191
10.8;VIII. Antigen Internalization;192
10.9;IX. Antigen Processing;196
10.10;X. The Biology of a Prime Antigen-Presenting Cell: The Dendritic Cell System;198
10.11;XI. Subversion of MHC Class II-Restricted Antigen Presentation by Pathogens;200
10.12;XII. Conclusions;202
10.13;References;203
11;Chapter 5. T-Cell Receptor Crossreactivity and Autoimmune Disease;220
11.1;I. Introduction;220
11.2;II. Crossreactivity and T-Cell Activation;220
11.3;III. Limits of TCR Crossreactivity: Peripheral Purging of Useless T-Cells;229
11.4;IV. TCR Crossreactivity and Autoimmune Disease: Viral-Derived Peptide Agonists;231
11.5;V. Cytokine Checkpoints in the Generation of Autoimmune Disease;235
11.6;References;237
12;Chapter 6. Strategies for Immunotherapy of Cancer;247
12.1;I. Introduction;247
12.2;II. Natural Protective Immunity against Cancer;250
12.3;III. Antigens Eliciting T Cell Responses Expressed by Virus-Associated Tumors;252
12.4;IV. Antigens Eliciting T Cell Responses by Non-Virus-Induced Tumors;251
12.5;V. Processing of Tumor Antigens;258
12.6;VI. Pivotal Role of Dendritic Cells and Tumor-Specific CD4+ Helper Cells in Tumor Immunity;257
12.7;VII. Fine Tuning of T Cell Responses by TNF(-R) Family Members;259
12.8;VIII. Escape Mechanisms of Tumors;263
12.9;IX. Cancer Therapy by Adoptive Transfer of T Cells;268
12.10;X. Design of Rational Cancer Vaccines Including Molecularly Defined Adjuvants;269
12.11;XI. Tumor Immunotherapy Based on Improved Costimulation via the CD28 Pathway;272
12.12;XII. Enhancement of Tumor-Specific T Cell Responses by Cytokines and by Cytokine-Transduced Tumor Cells;273
12.13;XIII. Monitoring of Tumor-Specific T Cell Responses;274
12.14;XIV. Immunotherapy with Monoclonal Antibodies;274
12.15;XV. Epilogue;275
12.16;References;275
13;Chapter 7. Tyrosine Kinase Activation in the Decision between Growth, Differentiation, and Death Responses Initiated from the B Cell Antigen Receptor;294
13.1;I. Abstract;294
13.2;II. Introduction;294
13.3;III. B Cell Antigen Receptor Signaling Controls Several Stages of B Lymphocyte Development;295
13.4;IV. Mechanisms Governing Different Cellular Responses from the Same Receptor;299
13.5;V. Iga and Igß Coreceptors in BCR Signaling;303
13.6;VI. The BCR-Associated Protein Tyrosine Kinases;306
13.7;VII. The Connections between Tyrosine Kinase Activation and Cellular Responses;315
13.8;VIII. Concluding Remarks;318
13.9;References;319
14;Chapter 8. The 3' IgH Regulatory Region: A Complex Structure in a Search for a Function;328
14.1;I. Introduction;328
14.2;II. Structure of the 3' IgH Control Region;328
14.3;III. Activity during B Cell Development;330
14.4;IV. Synergies between 3 Enhancers;231
14.5;V. DNA-Binding Proteins;235
14.6;VI. In a Search for a Function;341
14.7;VII. The Case of Humanized Mice;348
14.8;VIII. Conclusion;348
14.9;References;349
15;Index;358