Advances in Clinical Chemistry

1. Auflage 1994
ISBN: 978-0-08-056629-0
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, Band Volume 31, 283 Seiten

Reihe: Advances in Clinical Chemistry

'Its continuity of pertineence, excellence, and authority remains unbroken - a tribute to the skillful editing and writing involved. Every informed laboratory staff must have available a copy of this volume.'- CLINICAL CHEMISTRYFor more than thirty years, this serial has helped to broaden the technical scope and expand the scientific base of clinical chemistry. These volumes will clarify the areas of molecular biology, informatics, and the monitoring of physiological parameters in crticial situations as they pertain to clinical chemistry. Each volume of Advances in Clinical Chemistry contains an index, and each chapter includes references.

Autoren/Hrsg.

Inhaltsverzeichnis

1;Front Cover;1
2;Advances in Clinical Chemistry, Volume 31;4
3;Copyright Page;5
4;Contents;6
5;Contributors;10
6;Preface;12
7;Chapter 1. Multidrug Resistance in the Laboratory and Clinic;14
7.1;1. Introduction;15
7.2;2. Multidrug Resistance;16
7.3;3. MDRI Gene Family;17
7.4;4. Characterization of the P-Glycoprotein;21
7.5;5. ABC Superfamily of Transporters;25
7.6;6. MDR1 Gene and Protein Measurements;26
7.7;7. MDR1 Expression;35
7.8;8. MDR1 Modulation;43
7.9;9. Non-P-Glycoprotein-Mediated Multidrug Resistance;52
7.10;10. Summary;53
7.11;References;54
8;Chapter 2. Clinical Significance of Cardiac Contractile Proteins for the Diagnosis of Myocardial Injury;76
8.1;1. Introduction;76
8.2;2. A Survey of Results on Evaluating Cardiac Contractile Proteins in the Diagnosis of Myocardial Injury;87
8.3;3. Conclusions;103
8.4;References;105
9;Chapter 3. Prostatic Specific Antigen;112
9.1;1. Introduction;113
9.2;2. Historical Aspects;113
9.3;3. Structure of PSA;115
9.4;4. Circulating Forms;115
9.5;5. Physiological Function of PSA;116
9.6;6. Hormonal Regulation of PSA;116
9.7;7. Tissue Localization of PSA;118
9.8;8. Reference Values for PSA;119
9.9;9. Factors Affecting Serum PSA Level;120
9.10;10. Available Assays for the Measurement of PSA;124
9.11;11. Endogenous PSA Antibodies and Their Implications for PSA Assay;126
9.12;12. PSA and BPH;126
9.13;13. Role of PSA in Screening;127
9.14;14. Role of PSA in Staging;129
9.15;15. PSA in Monitoring Treatment Response;129
9.16;16. Role of PSA in Predicting Stage D2 Disease;133
9.17;17. PSA versus PAP;133
9.18;18. PSA as an Immunohistochemical Marker;135
9.19;19. Summary;136
9.20;References;137
10;Chapter 4. The Gonadotropin Surge in Human Reproduction: Endocrine and Biochemical Mechanisms;148
10.1;1. Introduction;148
10.2;2. The Ovarian Signal;150
10.3;3. Role of Estrogen in the Activation and Maintenance of the LH Surge Mechanism;154
10.4;4. Gonadotropin Surge Mechanism in the Hypothalamic—Pituitary Axis;157
10.5;5. The Gonadotropin Surge and Ovarian Activities;159
10.6;6. Role of Gonadotropin Surge in Ovulatory Processes;160
10.7;7. Feedback Mechanism and Pubertal Development;164
10.8;8. Gonadotropin Surge Mechanism and Reproduction;165
10.9;References;180
11;Chapter 5. Apoptosis and Programmed Cell Death in Health and Disease;190
11.1;1. Introduction;191
11.2;2. Programmed Cell Death as a Biological Phenomenon;197
11.3;3. Mechanism of Apoptosis;207
11.4;4. Measurement of Apoptosis;218
11.5;5. Clinical Significance of Apoptosis;228
11.6;6. Future Developments;237
11.7;References;242
12;Chapter 6. lmmunosensors for Clinical Analysis;260
12.1;1. Introduction;260
12.2;2. Principles of Immunosensors;263
12.3;3. Electrochemical Immunosensors;265
12.4;4. Piezoelectric Acoustic Immunosensors;274
12.5;5. Optical Immunosensors;276
12.6;6. Immunosensor-Coupled Immunoassay;282
12.7;7. Future Prospects of Immunosensor Research and Development;286
12.8;References;287
13;Index;290